SARS-CoV-2 Molecular Evolution in the United States

Preliminary analysis of the evolutionary characteristics of SARS-CoV-2 emerging in the United States.

Authors

Shihang Wang, Xuanyu Xu, Cai Wei, Sicong Li, Jingying Zhao, Yin Zheng, Xiaoyu Liu, Xiaomin Zeng, Wenliang Yuan, Sihua Peng

Journal of Medical Virology (JMV), 2022  |  Volume 94, Issue 1, Pages 310-317

Paper

Abstract

This study performed a comprehensive analysis of the molecular evolutionary characteristics of SARS-CoV-2 variants emerging in the United States. By analyzing genomic sequences of the virus collected from various time points and geographic regions, we identified key mutation patterns and evolutionary trends that provide insights into the virus’s adaptation and spread within the population.

Method

  • Genomic Data Collection: Collected and curated SARS-CoV-2 genomic sequences from the United States
  • Phylogenetic Analysis: Constructed phylogenetic trees to trace evolutionary relationships
  • Mutation Analysis: Identified key mutations in spike protein and other regions
  • Evolutionary Dynamics: Analyzed temporal and spatial mutation patterns to understand viral evolution

Key Results

  • Mutation Patterns: Identified characteristic mutation patterns in US SARS-CoV-2 strains
  • Evolutionary Trends: Characterized the evolutionary dynamics of the virus in the US population
  • Surveillance Insights: Provided scientific basis for future surveillance and prevention of virus variants
  • Public Health Implications: Results contributed to understanding the pandemic trajectory in the United States

BibTeX

@article{wang2022molecular,
  title={Molecular evolutionary characteristics of SARS-CoV-2 emerging in the United States},
  author={Wang, Shihang and Xu, Xuanyu and Wei, Cai and Li, Sicong and Zhao, Jingying and Zheng, Yin and Liu, Xiaoyu and Zeng, Xiaomin and Yuan, Wenliang and Peng, Sihua},
  journal={Journal of Medical Virology},
  volume={94},
  number={1},
  pages={310--317},
  year={2022},
  doi={10.1002/jmv.27331}
}